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Determination of finasteride, indapamide and tiemonium methyl sulphate using surface plasmon resonance band of silver nanoparticles. Rev. Sep. Sci. Mohamed Ayad M et al. 20 Oct 2019. RSS-2019-7-2/R2 | Download PDF | Regular article.


A simple and sensitive method was developed for spectrophotometric determination of finasteride, indapamide and tiemonium methyl sulphate in their pure form and in their pharmaceutical formulations. It was found that the studied drugs have the ability to reduce silver nitrate to silver nanoparticles (Ag NPs) in presence of sodium citrate as a stabilizing agent. Silver nanoparticles (Ag NPs) produce a very intense surface plasmon resonance peak at 423 nm that allows quantitative determination of the studied drugs. The calibration curves were linear with concentrations range of 0.50–5.00, 0.50-5.00 and 0.30-2.00 µg/mL for finasteride, indapamide and tiemonium methyl sulphate, respectively. The proposed method was successfully applied to determination of the studied drugs in their pharmaceutical formulations. Furthermore, content uniformity testing of the studied pharmaceutical tablets was also conducted.

Bioanalysis as a powerful tool in dentistry: The case of short-term and long-term release of monomers from dental composites. J. Appl. Bioanal. 22 March 2020. Samanidou VF and Diamantopoulou EI. JAB-2020-1-1/R2 |Download PDF | Special Issue “The Multidisciplinary Role of Bioanalysis“.


Novel materials used in preventive and restorative dentistry contain monomers with endocrine or cytotoxic properties, which can cause minimum or even severe damage to human body, when found in specific concentrations. The degradation of resin composite restorations after aging and/or storage in different solutions is associated with leaching monomers, like bisphenol A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), Urethane dimethacrylate (UDMA), Bisphenol A (BPA), which are potentially leading to toxicity and mutagenicity effects or cause allergic reactions. These monomers may cause health issues to patients, therefore their determination both in-vitro and in biological fluids e.g. saliva, blood serum/plasma and urine is significant. Moreover, analytical methods are necessary to investigate the rate of elution, as well as the conditions that mainly affect the mechanism of short-term and long-term release of monomers from dental composites. In this review article we present some of the techniques and methods used to determine the short-term and long-term release of these monomers from modern dental materials and prove that analytical chemistry and especially bioanalysis can be a powerful tool in dentistry.

Multi-Omics for biomedical applications.
J. Appl. Bioanal. 22 April 2020. Sharif Khan M and Azmir Jannatul. JAB-2020-2-3/R1 |Download PDF | Special Issue “Omics and Multi-Omics for biomedical applications“.


Multi-omics is a rising filed in –omics science. Despite progress in the multiple single –omics platform, the holistic look at the complex nature of the human cell, disease, and other biochemical pathways remain undiscovered. The multi-omics is considered the most integrated system currently available to obtain and measure the biochemical data-driven information for biomedical problems. The current review will look at the factors that play important roles in the rise of the multi-omics field and its application in biomedical studies.